Safari works just fine. I'll have you know that Safari supports more CSS3 than Opera, The Browser That Will Not Be Named (lol), Firefox, and almost exactly the same ones as Chrome, likely due to the fact that Chrome and Safari are both based off of WebKit. The only thing Chrome has on Safari is column-span, which is useless because the exact same thing can be done by just putting the text above the column area.
I will give Opera credit for needing a prefix on fewer things, but when it does you don't even know for sure whether it'll be -o- or -xv-, which is confusing.
Either way, The Browser That Will Not Be Named is the standard in web development simply due to it being the lowest common denominator, if you don't count CSS ruby stuff.